Impact of Individual Factors on DNA Methylation of ADME Genes: A
Individual differences in drug response have always existed in clinical
treatment. Many non-genetic factors show non-negligible impacts on
personalized medicine. Emerging studies have demonstrated epigenetic
could connect non-genetic factors and individual difference in
treatment. We used systematic retrieval methods and reviewed studies
that showed individual factors’ impact on DNA methylation of ADME genes.
In total, 63 studies were included, and half(n=32) were cohort studies.
Six aspects of individual factors were summarized from the perspective
of personalized medicine: parental exposure, environmental pollutants
exposure, obesity and diet, drugs, gender and others. The largest number
of studies (n=11) studied methylation of ABCG1. Most studies showed
these non-genetic factors could result in a significant DNA methylation
alteration in ADME genes, which subsequently affect the process of drug
metabolism. However, the underlying mechanisms remain unknown. Finally,
we put forward some views for future research.