Abstract
Background. Coronary heart disease is a serious threat to people’s life
and health, and timely intervention and treatment are important. This
study aims to investigate the clinical value of the serum C-reactive
protein/albumin ratio (CRP/ALB, CAR) and the neutrophil/lymphocyte ratio
(NE/LY, NLR) in predicting the extent of coronary artery disease.
Methods. A total of 649 patients hospitalized in the Department of
Cardiology of the Second People’s Hospital of Hefei with coronary
angiography from January 2019 to December 2021 were included for
retrospective analysis. The coronary artery disease group (n=406) and
the control group (n=243) were divided according to the angiographic
findings. The coronary artery disease group was divided into a mild
lesion group (GS <40, n=235) and a severe lesion group (GS 40,
n = 171) according to the Gensini score (GS). Compare the differences in
CAR and NLR between groups. Spearman analysis was used to test the
correlation between CAR, NLR and GS, logistic regression analysis was
used to screen independent influencing factors of coronary artery
disease and severe coronary lesions, and the ROC curve was used to
analyze the predictive value of CAR, NLR and the combination of both for
multiple lesions in coronary arteries. Results. CAR and NLR were higher
in the coronary artery disease group than in the control group, and CAR
and NLR were higher in the group with severe coronary lesions than in
the group with mild lesions (P < 0.05). Spearman correlation
analysis showed that CAR and NLR were positively correlated with GS (r
CAR = 0.519, P < 0.05; r
NLR = 0.492, P < 0.05). ROC analysis
showed that CAR, NLR and the combination of the two had predictive value
for multiple coronary lesions. The predictive efficacy was higher when
the two were combined than the individual indexes ( P <
0.05). Conclusion. CAR and NLR are independent predictors of the extent
of coronary artery lesions and can be used for diagnosing and evaluating
coronary heart disease.