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Genome protecting and genotoxic effects produced by derivatives of 1,4-dihydropyridine
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  • Elina Leonova,
  • Nadezhda Ryabokon,
  • Evita Rostoka,
  • Vitalijs Borisovs,
  • Astrida Velena,
  • Egils Bisenieks,
  • Gunars Duburs,
  • Maija Dzintare,
  • Nikolajs Sjakste,
  • Roza Goncharova
Elina Leonova
University of Latvia
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Nadezhda Ryabokon
SSI Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
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Evita Rostoka
University of Latvia
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Vitalijs Borisovs
University of Latvia
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Astrida Velena
Latvian Institute of Organic Synthesis
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Egils Bisenieks
Latvian Institute of Organic Synthesis
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Gunars Duburs
Latvian Institute of Organic Synthesis
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Maija Dzintare
Latvian Academy of Sport Education
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Nikolajs Sjakste
University of Latvia

Corresponding Author:[email protected]

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Roza Goncharova
SSI Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
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Abstract

The review summarizes data on genome protecting and genotoxic action of 1,4-dihydropyridines (DHP) with main focus on the compounds synthesized in the Latvian Institute of Organic synthesis. Most of these compounds manifest very low calcium channel blocking activity, thus considered to be “unusual” 1,4-DHP. Some of these compounds decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. Some water-soluble 1,4-DHP protect DNA against damage produced by hydrogen peroxide, radiation and peroxynitrite. In these molecules capability to protect DNA cohabitates with DNA-binding activity. Possible mechanisms of above effects are discussed.