Paraneoplastic encephalitis as a rare paraneoplastic syndrome of
adrenocortical carcinoma: A rare case report.
Paraneoplastic neurologic syndromes (PNS) are rare in pediatrics and are
understood to be consequences of cross-reactivity against various
neuroendocrine antigens expressed on cancer cells. Here, we report a
case of autoimmune encephalitis, a type of paraneoplastic neurologic
syndrome that was associated with a case of adrenocortical carcinoma and
had some clinical response to immunosuppressive therapy. Adrenocortical
carcinoma is a rare tumor with controversial tissue of origin but
expresses various neuroendocrine antigens that could be the possible
mechanism for this rare yet interesting association.