Legends of Allergy and Immunology -- Dean D. Metcalfe
As many other physicians and researchers, we have had the great pleasure
to be fellows in the laboratory of Dean Metcalfe, the Laboratory of
Allergic Diseases, National Institute of Allergic and Infectious
Diseases (NIAID), NIH, Bethesda, USA (Figure (#fig-cap-0001)).
The open atmosphere, research driven by curiosity, hypotheses
originating from clinical observations, and mutual trust and respect are
the cornerstones of Dean’s mentorship. Dean and his laboratory have made
major contributions on mast cell biology, from basic studies on the
regulation of mast cell development and functions, to clinical studies
on mast cells in diseases, such as systemic mastocytosis. After more
than 50 years of exploring human mast cells, Dean’s impact on what we
know today about these cells, their biology and how they affect diseases
is outstanding and unique.