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  • Laura Segatori,
  • Bhagyashree Bachhav,
  • Jacopo de Rossi,
  • Carlos D. Llanos
Laura Segatori
Rice University

Corresponding Author:[email protected]

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Bhagyashree Bachhav
Rice University
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Jacopo de Rossi
Rice University
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Carlos D. Llanos
Rice University
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The production of high-quality recombinant proteins is critical to maintaining a continuous supply of biopharmaceuticals, such as therapeutic antibodies. Engineering mammalian cell factories presents a number of limitations typically associated with proteotoxic stress induced upon aberrant accumulation of off-pathway protein folding intermediates, which eventually culminate with the induction of apoptosis. Recent progress in mammalian synthetic biology provides unique opportunities to endow cells with programmable, user-defined behaviors, thereby addressing some of the challenges of current methods. In this review, we will discuss advances in synthetic biology to design efficient strategies for biomanufacturing.
20 Dec 2022Submitted to Biotechnology and Bioengineering
20 Dec 2022Review(s) Completed, Editorial Evaluation Pending
20 Dec 2022Submission Checks Completed
20 Dec 2022Assigned to Editor
20 Dec 2022Reviewer(s) Assigned
18 Jan 2023Editorial Decision: Revise Major
13 Feb 20231st Revision Received
16 Feb 2023Submission Checks Completed
16 Feb 2023Assigned to Editor
16 Feb 2023Review(s) Completed, Editorial Evaluation Pending
16 Feb 2023Reviewer(s) Assigned
27 Feb 2023Editorial Decision: Accept