loading page

Features of cortical morphology in aneurysmal subarachnoid hemorrhage
  • +4
  • Fuxiang Chen,
  • Ting Yu,
  • Yaqing Kang,
  • Yuanxiang Lin,
  • Linsun Dai,
  • Lianghong Yu,
  • Dengliang Wang
Fuxiang Chen
First Affiliated Hospital of Fujian Medical University

Corresponding Author:[email protected]

Author Profile
Ting Yu
Fujian Medical University Affiliated Fuzhou First Hospital
Author Profile
Yaqing Kang
First Affiliated Hospital of Fujian Medical University
Author Profile
Yuanxiang Lin
First Affiliated Hospital of Fujian Medical University
Author Profile
Linsun Dai
First Affiliated Hospital of Fujian Medical University
Author Profile
Lianghong Yu
First Affiliated Hospital of Fujian Medical University
Author Profile
Dengliang Wang
First Affiliated Hospital of Fujian Medical University
Author Profile

Abstract

Background and purpose: Structural brain damage was discovered in patients after aneurysmal subarachnoid hemorrhage (SAH). However, changes of cortical gray matter characteristics remain unknown. The aim of this study was to test the hypothesis that cortical morphometry features were disrupted after aneurysmal SAH. Methods: Structural MRI were acquired from 115 aneurysm patients and 32 healthy controls. The FreeSurfer pipeline was used to cortical construction for all subjects. Further, patients were separately divided into subgroups based on presence of SAH, clipping or coiling, and length of follow-up after treatment. Differences in cortical thickness, surface area and volume between groups were compared after controlling for covariates. Subsequently, correlation analyses were performed between abnormal cortical features and clinical data. Results: The vertex-wise analyses revealed that aneurysm patients present smaller cortical volume in the right superiorfrontal gyrus than healthy controls, but there was no significant difference for cortical thickness or surface area. As expected, both microsurgical clipping and postoperative follow-up time had no significant effect on cortical morphological measures following subgroups analyses. We only found patients who with ruptured aneurysm had decreased surface area in the left superiorparietal gyrus, left precuneus, and right superiorfrontal gyrus in comparison to the unruptured group. However, positive finding of decreased regional gray matter volume and surface area were disappeared after adding the total intracranial volume as additional covariate. Conclusion: These findings enhance our understanding for the mechanism of brain damage following aneurysmal SAH, and additional support the advantages of brain protection of keyhole surgery for aneurysm treatment.