Plant-based green-formulated cobalt nanoparticles: Introducing a novel
chemotherapeutic supplement for the treatment of esophageal cancer
Abstract
Linum usitatissimum is one of the popular medicinal plants. The plant
has many pharmaceutical uses in traditional medicine. In this study,
cobalt nanoparticles were synthesized according to green chemistry rules
using the aqueous extract of Linum usitatissimum. The green-synthesized
CoNPs@ L. usitatissimum were characterized using different techniques
such as EDX, FE-SEM, XRD, and FT-IR. The FE-SEM results confirm
spherical morphology for the nanoparticles with size of 38.42 to 75.26
nm. The properties of CoNPs@ L. usitatissimum against common human
esophageal cancer cell lines i.e. KYSE-270, OE33, ESO26 and FLO-1 were
evaluated. The antioxidant test with DPPH free radical indicates the
significant antioxidant properties of CoNPs@ L. usitatissimum. The IC50
of the CoNPs@ L. usitatissimum was 359, 176, 371, and 387 against
KYSE-270, OE33, ESO26 and FLO-1, respectively. It seems that the
anti-human esophageal cancer effect of cobalt nanoparticles mediated by
Linum usitatissimum leaf aqueous extract is due to their antioxidant
effects.