loading page

Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations
  • Guersel Caliskan,
  • Yunus Demiray,
  • Oliver Stork
Guersel Caliskan
Otto von Guericke Universitat Magdeburg

Corresponding Author:[email protected]

Author Profile
Yunus Demiray
Otto von Guericke Universitat Magdeburg
Author Profile
Oliver Stork
Otto von Guericke Universitat Magdeburg
Author Profile


A major challenge in neuroscience is to pinpoint neurobiological correlates of specific cognitive and neuropsychiatric traits. At the mesoscopic level, promising candidates for establishing such connections are brain oscillations that can be robustly recorded as local field potentials with varying frequencies in the hippocampus in vivo and in vitro. Inbred mouse strains show natural variation in hippocampal synaptic plasticity (e.g., long-term potentiation), a cellular correlate of learning and memory. However, their diversity in expression of different types of hippocampal network oscillations has not been fully explored. Here, we investigated hippocampal network oscillations in three widely used inbred mouse strains: C57BL/6J (B6J), C57BL/6NCrl (B6N) and 129S2/SvPasCrl (129) with the particular aim to identify common oscillatory characteristics in inbred mouse strains that show aberrant emotional/cognitive behaviour (B6N and 129) and compare them to “control” B6J strain. First, we detected higher gamma oscillation power in the hippocampal CA3 of both B6N and 129 strains. Second, an increased incidence of hippocampal sharp wave-ripple (SW-R) transients was evident in these strains. Third, we observed prominent differences in the densities of distinct interneuron types and CA3 associative network activity which are indispensable for sustainment of mesoscopic network oscillations. Together, these results supports the notion that in vitro hippocampal network oscillations, similar to classical plasticity read-outs measured in hippocampal slices, can be used as robust reductionist models to study electrophysiological correlates of emotional and cognitive phenotypes. Importantly, we add further evidence to profound physiological differences among inbred mouse strains commonly used in neuroscience research.
15 Nov 2022Submitted to European Journal of Neuroscience
16 Nov 2022Submission Checks Completed
16 Nov 2022Assigned to Editor
17 Nov 2022Review(s) Completed, Editorial Evaluation Pending
01 Dec 2022Reviewer(s) Assigned
14 Jan 2023Editorial Decision: Revise Major
16 May 20231st Revision Received
17 May 2023Assigned to Editor
17 May 2023Review(s) Completed, Editorial Evaluation Pending
17 May 2023Submission Checks Completed
17 May 2023Reviewer(s) Assigned
27 Jun 2023Editorial Decision: Revise Major
03 Jul 20232nd Revision Received
04 Jul 2023Assigned to Editor
04 Jul 2023Submission Checks Completed
04 Jul 2023Review(s) Completed, Editorial Evaluation Pending
04 Jul 2023Reviewer(s) Assigned
24 Jul 2023Editorial Decision: Accept