Objectives: To study the effectiveness of Sucralfate suspension oral rinse compared to normal saline alone for pain reduction and wound healing promotion in open oral surgical wounds. The primary outcome of this study was postoperative pain VAS score reduction. The secondary outcome was wound healing promotion based on wound grade and maximal wound length reduction Study Design: Randomized controlled trial Setting: Department of Otolaryngology, King Chulalongkorn Memorial Hospital Materials and Methods: A total of 30 patients with secondary healing intraoral surgical wound were enrolled in this study. Sucralfate suspension (1g/5ml) was prescribed to a randomized experimental group as an oral rinse every 6 hours for 14 days in addition to standard postoperative care. Postoperative pain VAS score, wound grade and wound length were collected and compared with baseline from initial to final visit during a 2-week period. Results: The mean change of VAS score was significantly lower from baseline in the Sucralfate group at day3 (-0.77 in control and -2.15 in Sucralfate, p<0.05) and day 7 (-2.15 in control and -3.62 in Sucralfate, p<0.05). Wound grade distribution over time was the same in both Sucralfate and control groups. The mean change of wound length was not significantly different between the two groups. No adverse reaction to Sucralfate was reported during the study participation. Conclusions: Sucralfate suspension oral rinse can be recommended as an effective topical analgesic solution in postoperative secondary healing of intraoral wound with no significant interference. Benefits to wound healing promotion have yet to be proven. Keywords: Sucralfate, oral wound, oral surgery, pain, wound healing, postoperative, analgesia