Difficult-to-treat Diabetes Insipidus in a Patient with Midline Defect:
A Case Report
Holoprosencephaly (HPE) is a complex brain malformation resulting from
incomplete cleavage of the prosencephalon, occurring between the 18th
and 28th day of gestation. Endocrinologic dysfunctions such as diabetes
insipidus (DI), hypothyroidism, and growth hormone deficiency are common
in HPE and correlated with the degree of hypothalamic non-separation.