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Inhalation Of Carboxymethyl Chitosan Alleviates Post-Traumatic Tracheal Fibrosis
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  • Rushi Huang,
  • Shicai Chen,
  • Xianmin Song,
  • Hongliang Zheng
Rushi Huang
The First Affiliated Hospital of Naval Medical University

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Shicai Chen
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Xianmin Song
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Hongliang Zheng
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Objectives: The aim of this study was to investigate whether the inhalation of CM-chitosan alleviates tracheal fibrosis in a rabbit. Methods: We designed a method of cauterizing rabbit tracheal stenosis with a spherical electrode electrocoagulation. Twenty New Zealand white rabbits were randomly divided into two groups of ten subjects each: the experimental group using CM-chitosan and the control group.All the subjects were successfully established tracheal damage model using electrocoagulation. On top of this, the experimental group was given 28-days long inhalation of CM-chitosan and the control group was inhaled saline.The effect of the inhalation of CM-chitosan were measured in tracheal fibrosis. Results: Laryngoscopy revealed that the tracheal cross-sectional area of rabbits in the drug group was smaller than that in the saline group. In the drug group, no abnormality was found in Heart, liver, spleen, lung and kidney tissues in HE stain and in non-surgical trachea under scanning electron microscope. Conclusion: These findings demonstrated that the inhalation of CM-chitosan mitigated post-traumatic tracheal fibrosis in a rabbit model,which provided a new way for further treatment study of tracheal stenosis. Key Words: Tracheal fibrosis, tracheal stenosis, CM-chitosan, inhalation, rabbits.