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Acute myeloid leukemia superimposed on hemophagocytic lymphohistiocytosis after COVID19 vaccination
  • Shyam H. Bhatt,
  • Violet Borowicz,
  • Michael Stump
Shyam H. Bhatt
Virginia Tech Carilion School of Medicine

Corresponding Author:[email protected]

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Violet Borowicz
Virginia Tech Carilion School of Medicine
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Michael Stump
Carilion Roanoke Memorial Hospital
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Hemophagocytic lymphohistiocytosis (HLH) is a multi-system inflammatory condition that has been observed as a rare adverse effect of the COVID19 vaccination. AML occurring in a pediatric patient as HLH enters remission has never been documented previously. Our case describes a 17-year-old male who was treated for this pathology with immunosuppressants and two different chemotherapeutic protocols. Due to the aggressive nature of his MLL-rearranged genetic profile, this cancer was pervasive and refractory to treatment.