loading page

The effect of Vitamin D supplementation among antenatal women with Gestational diabetes mellitus with Vitamin D deficiency: A Randomised Controlled Trial
  • +2
  • Supriya Kumari,
  • Saubhagya Jena,
  • Sweta singh,
  • Manaswini Mangaraj,
  • Gautom saharia
Supriya Kumari
AIIMS Bhubaneswar

Corresponding Author:[email protected]

Author Profile
Saubhagya Jena
AIIMS Bhubaneswar
Author Profile
Sweta singh
AIIMS Bhubaneswar
Author Profile
Manaswini Mangaraj
AIIMS Bhubaneswar
Author Profile
Gautom saharia
AIIMS Bhubaneswar
Author Profile

Abstract

Objective This study aimed to assess the effectiveness of high dose vitamin D as compared to that of standard dose in women with GDM having vitamin D deficiency. Design Randomized controlled trial Setting This study was conducted at the Department of Obstetrics & Gynecology, All India Institute of Medical Sciences, (AIIMS) Bhubaneswar. Population or sample 76 women with GDM having vitamin D deficiency were included in this study. Methods Participants were randomly recruited in intervention and control group. Participants of the intervention group were provided with 60,000 IU of vitamin D every two weeks (upto a maximum of ten doses) and participants of the control group were provided with standard dose of vitamin D (500 IU/day). All the participants were assessed for glycemic control and perinatal outcomes. Main outcome measures Perinatal outcomes, blood sugar levels and change in insulin requirement between the two groups. Results Among 68 participants, mean difference of 1.06 mg/dl and 1.48 mg/dl was observed for fasting and post-prandial blood glucose levels. Mean insulin requirement increased by 5 units in control group during pregnancy, whereas it was reduced by 1.1 unit in intervention group. Poor perinatal outcome was observed among 65.2% of the participants and 34.8% amongst the participants in the intervention group. Conclusion High dose of vitamin D supplementation is useful for better glycemic control and preventing poor perinatal outcome among GDM women with vitamin D deficiency. Routine Vitamin D testing and high dose supplementation in antenatal women with proven Vitamin D deficiency should be considered.