Objectives: The aim of the study is to identify the success rate of a repeat cycle of induction of labour (IOL) with prostaglandins, and any association between smoking and patient response to prostaglandin. Design: Retrospective cohort study. Setting: Basildon and Thurrock University Hospital, UK. Sample: IOL data from patients at Basildon University Hospital, between 01/01/2021 and 30/03/2021 were included. Methods: Data were retrieved from hospital records and categorised by prostaglandin cycle(s), administration of oxytocin, artificial rupture of membranes (ARM), spontaneous rupture of membranes (SROM), smoking status, patient BMI, age, ethnicity, gestation age, Bishop score, and delivery method (assisted, unassisted, or Caesarean (C-)section). The data were analysed using chi-square, binomial and multinomial logistic regression. Main Outcome Measures: Success rate was interpreted from relative frequencies of delivery method (unassisted, assisted or C-section). Results: Unassisted vaginal delivery (n =121; 48.0%) was the most common outcome with prostaglandin IOL followed by C-section (n = 105 41.7%). Only 10.3% had an assisted vaginal delivery. Of those who had a repeated IOL cycle, 85.7% had a C-section. There was no difference in prostaglandin administration by smoking status or any association between smoking status and mode of delivery in IOL. Conclusion: Repeat cycle of IOL does not enhance the vaginal delivery with only 14.3% unassisted vaginal births. There was no evidence that smoking impacted on response to prostaglandins or method of delivery. Funding: There was no funding for this study. Keywords: artificial rupture of membranes; C-section; repeat induction of labour; spontaneous rupture of membranes; Unassisted vaginal delivery.