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Facile preparation of zinc nanoparticles mediated by plant aqueous extract and assessment of the antioxidant, cytotoxicity and anti-human gastric carcinoma properties
  • Huang Fang
Huang Fang
Huazhong University of Science and Technology

Corresponding Author:[email protected]

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In this study, the Zn nanoparticles was synthesized using the peel extract of Citrus aurantium. The nanoparticles was characterized by different chemical technique including UV-Vis. and FT-IR spectroscopy, and SEM technique. The results revealed a spherical shape in the average ‎size of 41.17 nm was identified for the green-synthesized nanoparticles. In the antioxidant test, the IC50 of nanoparticles and BHT against DPPH free radicals were 115 and 96 µg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with nanoparticles were assessed by MTT assay for 48h about the cytotoxicity and anti-human gastric cancer properties on normal (HUVEC) and gastric cancer cell lines i.e. NCI-N87 and MKN45. The IC50 of nanoparticles were 278 and 256 µg/mL against NCI-N87 and MKN45 cell lines, respectively. The viability of malignant gastric cell line reduced dose-dependently in the presence of Zn nanoparticles. It seems that the anti-human gastric cancer effect of recent nanoparticles is due to their antioxidant effects. After evaluating the effectiveness of this formulation in clinical trial researches, it can be a good alternative to chemotherapy drugs.
16 Sep 2022Submitted to Micro & Nano Letters
19 Sep 2022Submission Checks Completed
19 Sep 2022Assigned to Editor
26 Sep 2022Reviewer(s) Assigned
26 Oct 2022Review(s) Completed, Editorial Evaluation Pending
26 Oct 2022Editorial Decision: Revise Minor
24 Nov 20221st Revision Received
19 Dec 2022Submission Checks Completed
19 Dec 2022Assigned to Editor
03 Jan 2023Reviewer(s) Assigned
03 Jan 2023Review(s) Completed, Editorial Evaluation Pending
04 Jan 2023Editorial Decision: Accept