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Expression of AQP8 in serum of patients with Meniere's disease and its value in evaluating the degree of hydrolabyrinth and predicting prognosis
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  • Rui Zhao,
  • Tianhua Yi,
  • Qinqin Wu,
  • Xuemei Liu,
  • Jianqiao He,
  • Yufang Tan
Rui Zhao
The First Affiliated Hospital of Shaoyang University,Shaoyang City
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Tianhua Yi
The First Affiliated Hospital of Shaoyang University
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Qinqin Wu
The First Affiliated Hospital of Shaoyang University
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Xuemei Liu
The First Affiliated Hospital of Shaoyang University
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Jianqiao He
The First Affiliated Hospital of Shaoyang University
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Yufang Tan
The First Affiliated Hospital of Shaoyang University
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Abstract

Abstract Objective To explore the value of serum aquaporin 8 (AQP8) expression in evaluating the degree of hydrolabyrinth and predicting prognosis in patients with Meniere’s disease. Methods 105 patients with Meniere’s disease in our hospital were included in the Meniere’s disease group.Another 102 healthy subjects in our hospital were included as the control group. The multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in patients with Meniere’s disease. Results The expression of serum AQP8 mRNA in the Meniere’s disease group was greatly higher than that in the control group (P<0.05). Serum AQP8 mRNA expression in severe hydrops group was greatly higher than that in mild hydrops group and no endolymphatic hydrops group, and serum AQP8 mRNA expression in mild hydrops group was greatly higher than that in no endolymphatic hydrops group (P<0.05). The course of disease, the proportion of severe hydrops and the expression of serum AQP8 mRNA in the poor prognosis group were greatly higher than those in the good prognosis group (P<0.05). The area under the curve (AUC) of serum AQP8 mRNA for predicting poor prognosis in Meniere’s disease patients was 0.812 (95%CI: 0.702-0.922), with a sensitivity of 81.0% and a specificity of 70.2%. AQP8 mRNA was an independent risk factor for poor prognosis in patients with Meniere’s disease (P<0.05). Conclusion AQP8 mRNA is associated with the degree of hydrolabyrinth in patients with Meniere’s disease, and has a high performance in predicting prognosis.
30 Aug 2022Submitted to Clinical Otolaryngology
15 Sep 2022Assigned to Editor
15 Sep 2022Submission Checks Completed
23 Sep 2022Reviewer(s) Assigned