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Cystic fibrosis-related mortality trends in Mexico between 1999 -- 2020
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  • Adriana Bustamante,
  • Lucia Fernandez,
  • Lissette Rivas,
  • Roberto Mercado Longoria
Adriana Bustamante
Hospital Universitario Dr Jose Eleuterio Gonzalez
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Lucia Fernandez
Hospital Universitario Dr Jose Eleuterio Gonzalez
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Lissette Rivas
Hospital Universitario Dr Jose Eleuterio Gonzalez
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Roberto Mercado Longoria
Hospital Universitario Dr Jose Eleuterio Gonzalez
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Abstract

Background. Cystic fibrosis (CF) is an autosomal recessive disorder associated with an increased susceptibility to respiratory infections that cause progressive decline in lung function and lead to lung damage and chronic respiratory failure. To analyze the CF-related mortality trends in the Mexican population during a 22-year period.  We conducted a mortality trend analysis using death certificates data. Trends in CF-specific and in age-specific mortality rates were evaluated using Joinpoint regression analysis. Among subjects ≤40 years, 1184 CF-related deaths were identified. In 1999–2009 median age at death was 7 years compared to 10 years in 2010–2020. Overall mortality rate increased from 0.03 per 100,000 in 1999 to 0.06 per 100,000 in 2020. A decline in mortality rate for patients ≤28 days and an increase in mortality rate in older age groups was observed. Conclusion. The increasing trend in overall mortality, associated with a downward trend in neonatal mortality and an increase in median age at death is conceivably due to enhanced diagnosis, as well as major advances in treatment modalities, leading to higher survival rates. Key words: age at death, cystic fibrosis, epidemiology, low- and middle-income countries, mortality, survival rate.
30 Aug 2022Submitted to Pediatric Pulmonology
01 Sep 2022Assigned to Editor
01 Sep 2022Submission Checks Completed
03 Sep 2022Reviewer(s) Assigned
12 Sep 2022Review(s) Completed, Editorial Evaluation Pending
15 Sep 2022Editorial Decision: Revise Major