Objective: Nasal septum perforation is an anatomical defect located in the nasal septal cartilage/bone and mucosa. The most common cause of nasal septal perforations is septoplasty. Repair of nasal septal perforations is difficult regardless of the surgical technique due to its location and health of the surrounding tissues. Currently, no technique has been defined to be used for closure of all nasal septal perforations. We aimed to present our bipediculated crescent-shaped unilateral slide flap technique, which we designed and used as a novel technique for closure of nasal septal perforations, and its surgical results. Design: Retrospective study. Settings: Single-center patients with nasal septum perforation. Participants: 36 patients who underwent nasal septum perforation repair in our clinic between 2018-2022. All patients underwent surgical procedure with the same technique by the same surgeon. Main Outcome Measures: Nasal septum perforation closure success at 6th month follow-up. Results: Thirty-six patients, including 20 males and 16 females, were included in the study. The mean age of the patients was 35,58±9,6. The most common cause of nasal septal perforation was previous septal surgeries. The septal perforation dimensions of the patients were between 5-23 mm and the mean was 13,86±5,4 mm. Septal perforation closure rate was determined as 94.4% in the 6 months follow-up results after surgery. Conclusion: Bipediculated crescent shaped unilateral sliding flap is an effective, easy and novel technique in the repair of nasal septal perforations.