Dyslipidemia and atherogenic indices in children with Transfusion
Objective- Assessment of lipid profile and atherogenic lipid
indices in children with transfusion dependent thalassemia (TDT) and to
compare them with matched healthy children. Method- The study
group consisted of total 72 patients of TDT aged between 3-14 years
while the control group had 83 age and sex matched healthy children.
Estimation of fasting lipid profile and lipid indices - atherogenic
index of plasma (AIP), Castelli risk index I and II, atherogenic
coefficient were calculated and compared between the two groups.
Result – Compared to the control group, the mean LDL, HDL, and
cholesterol level were significantly lower among case group (P value
< 0.001). The mean VLDL and triglycerides were significantly
higher in case group (P value < 0.001). Lipid indices
including atherogenic index of plasma (AIP), Castelli risk index I and
II, atherogenic coefficients were significantly higher in TDT children.
Conclusion- Dyslipidemia and increased risk of atherosclerosis
were found in children of TDT as they had elevated atherogenic lipid
indices. Our study underlines the importance of routine use of these
indices in TDT children. Future studies should focus on lipid indices in
this high group of children so that preventive strategies can be planned