loading page

Diagnosis and Management of Food Allergy Induced Gastroesophageal Reflux Disease in young Children -- EAACI Position Paper
  • +9
  • Rosan Meyer,
  • Yvan Vandenplas,
  • Adriana Chebar Lozinsky,
  • Mario Viera,
  • Roberto Berni Canani,
  • Christophe Dupont,
  • Pinar Uysal,
  • Ozlem Cavkaytar,
  • Rebecca Knibb,
  • David Fleischer,
  • Anna Nowak-wegrzyn,
  • Carina Venter
Rosan Meyer
Imperial College London Department of Life Sciences

Corresponding Author:[email protected]

Author Profile
Yvan Vandenplas
Vrije Universiteit Brussel - Brussels Health Campus
Author Profile
Adriana Chebar Lozinsky
Murdoch Children's Research Institute
Author Profile
Mario Viera
Center for Pediatric Gastroenterology - Hospital Pequeno Príncipe Curitiba Brazil
Author Profile
Roberto Berni Canani
Department of Translational Medical Science and ImmunoNutritionLab at CEINGE – Advanced Biotechnologies Research Center University of Naples “Federico II” Naples Italy
Author Profile
Christophe Dupont
Hopital universitaire Necker-Enfants malades
Author Profile
Pinar Uysal
Department of Allergy and Clinical Immunology Adnan Menderes University Aydin Turkey
Author Profile
Ozlem Cavkaytar
Department of Pediatric Allergy and Immunology Istanbul Medeniyet University Faculty of Medicine Goztepe Prof Suleyman Yalcin City Hospital Istanbul Turkey
Author Profile
Rebecca Knibb
Aston University School of Psychology
Author Profile
David Fleischer
University of Colorado Denver University of Colorado Medicine
Author Profile
Anna Nowak-wegrzyn
Icahn School of Medicine at Mount Sinai Department of Pediatrics
Author Profile
Carina Venter
University of Colorado Denver University of Colorado Medicine
Author Profile


Gastro-oesophageal reflux (GOR) and food allergy (FA) are common conditions, especially during the first 12 months of life. When GOR leads to troublesome symptoms, that affect daily functioning of the infant and family, it is referred to GOR disease (GORD). The role of food allergens as a cause of GORD remains controversial. This European Academy of Allergy and Clinical Immunology (EAACI) position paper aims to review the evidence for FA-associated GORD in young children and translate this into clinical practice that guides healthcare professionals through the diagnosis of suspected FA-associated GORD and the medical and dietary management. The Task Force (TF) on non-IgE mediated allergy consists of EAACI experts in paediatric gastroenterology, allergy, dietetics and psychology from Europe, United Kingdom, United States, Turkey and Brazil. Six clinical questions were formulated, amended and approved by the TF to guide this publication. A systematic literature search using PubMed, Cochrane and EMBASE databases (until June 2021) using a predefined inclusion criteria based on the 6 questions was used. The TF also gained access to the database from the European Society of Paediatric Gastroenterology and Hepatology working group, who published guidelines on GORD and ensured that all publications used within that position paper were included. For each of the 6 questions, practice points were formulated, followed by a modified Delphi method consisting of anonymous web-based voting that was repated with modified practice points where required, until at least 80% consensus for each practice point was achieved. This TF position paper shares the process, the discussion and consensus on all practice points on FA-associated GORD.
12 Jul 2022Submitted to Pediatric Allergy and Immunology
20 Jul 2022Reviewer(s) Assigned
07 Aug 2022Review(s) Completed, Editorial Evaluation Pending
15 Aug 2022Editorial Decision: Revise Minor
27 Aug 20221st Revision Received
27 Aug 2022Review(s) Completed, Editorial Evaluation Pending
06 Sep 2022Editorial Decision: Accept