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Predictors of non-functional larynx following (chemo)radiotherapy for locally advanced laryngeal cancer
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  • Kristijonas Milinis,
  • Rhydian King,
  • Jeffrey Lancaster@liverpoolft.nhs.uk ,
  • Rachel Brooker,
  • Rebecca Zammitt,
  • Mark Wilkie,
  • Jason Fleming,
  • Katharine Davies
Kristijonas Milinis
Liverpool University Hospitals NHS Foundation Trust
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Rhydian King
Liverpool University Hospitals NHS Foundation Trust
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Jeffrey Lancaster@liverpoolft.nhs.uk
Liverpool University Hospitals NHS Foundation Trust
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Rachel Brooker
Clatterbridge Cancer Centre NHS Foundation Trust
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Rebecca Zammitt
Clatterbridge Cancer Centre NHS Foundation Trust
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Mark Wilkie
University Hospital Aintree
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Jason Fleming
Liverpool University Hospitals NHS Foundation Trust
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Katharine Davies
Liverpool University Hospitals NHS Foundation Trust
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Abstract

• Non-functional larynx (NFL) was found to affect 30.9 % of patients with locally advanced laryngeal cancer who underwent curative non-surgical laryngeal preservation treatment for stage III/IV disease • The key measures of NFL were long-term gastrostomy and tracheostomy dependence, functional laryngectomy and chronic aspiration. • Multivariate analyses identified current smoking to be associated with 6.8-fold increase in NFL • Patients with pre-treatment hemi-laryngeal fixation were 3.4 times more likely to experience locoregional recurrence.