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Effects of light size and intensity on photoconductive effect-based optically-induced dielectrophoresis for three-dimensional manipulation
  • Huanzhou Yang,
  • Zuobin Wang
Huanzhou Yang
Changchun University of Science and Technology

Corresponding Author:1464089527@qq.com

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Zuobin Wang
Changchun University of Science and Technology
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Abstract

In this paper, the effect of light size and intensity on photoconductive effect-based optically-induced dielectrophoresis (ODEP) for three-dimensional manipulation of cells is studied. The photoconductive effect-based ODEP enabled the three-dimensional manipulation of multiple cells, whether normal cells or cancer cells. When the light spot size is similar to the cell and the photoconductive layer resistance is about 150 MΩ, the spot repels other cells after manipulating a single cell. When the light spot size is much larger than the cell and the photoconductive layer resistance is about 120 MΩ, multiple cells are controlled inside the spot and distributes in the same plane. When the light intensity is increased and the photoconductive layer resistance is about 40 MΩ, the cells are manipulated in three-dimensions. Using a light spot similar in size to the cells to gather specific cells at different locations into a specific area, and then increasing the light intensity enabled three-dimensional manipulation. We find that the cells three-dimensional manipulation by ODEP is achieved only when the photoconductive effect induced by the light pattern reaches a higher intensity. The realization of ODEP-based three-dimensional manipulation is related to the spot size and the photoconductive layer resistance determined by light intensity.
03 Aug 2022Submitted to Biotechnology Journal
03 Aug 2022Submission Checks Completed
03 Aug 2022Assigned to Editor
05 Aug 2022Reviewer(s) Assigned
12 Sep 2022Editorial Decision: Revise Major
22 Oct 20221st Revision Received
22 Oct 2022Submission Checks Completed
22 Oct 2022Assigned to Editor
24 Oct 2022Reviewer(s) Assigned
05 Nov 2022Review(s) Completed, Editorial Evaluation Pending
08 Nov 2022Editorial Decision: Revise Major