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QUARTO III. Response rate in cardiac resynchronization therapy patients implanted with a left ventricular quadripolar lead and the MultiPoint TM Pacing feature activated.
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  • Joaquín Osca,
  • Jaume Francisco-Pascual,
  • Javier Martínez-Basterra,
  • Juan Gabriel Martinez,
  • Hipólito Reis,
  • Mario Oliveira,
  • Bieito Campos,
  • Javier Balaguer,
  • Jerónimo Rubio Sanz,
  • Ricardo Pavón-Jiménez,
  • Julio Hernández Afonso,
  • Jose Miguel Ormaetxe,
  • Jose Zamorano,
  • Pilar Santamaría,
  • Javier Alzueta
Joaquín Osca
Hospital Universitari i Politecnic La Fe
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Jaume Francisco-Pascual
Hospital Universitari Vall d'Hebron
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Javier Martínez-Basterra
Clinica Universidad de Navarra
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Juan Gabriel Martinez
Hospital General Universitari d'Alacant
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Hipólito Reis
Hospital de Santo Antonio dos Capuchos
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Mario Oliveira
Hospital Santa Marta
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Bieito Campos
Hospital Universitari Arnau de Vilanova
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Javier Balaguer
Hospital General Universitario de Guadalajara
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Jerónimo Rubio Sanz
Hospital Clinico Universitario de Valladolid Servicio de Cardiologia
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Ricardo Pavón-Jiménez
Hospital Universitario de Valme
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Julio Hernández Afonso
Hospital Universitario Nuestra Senora de la Candelaria
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Jose Miguel Ormaetxe
Hospital Universitario Basurto
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Jose Zamorano
MDLZ Espana Madrid
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Pilar Santamaría
Abbott Cardiovascular Espana SA
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Javier Alzueta
Hospital Universitario Virgen de la Victoria
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Abstract

BACKGROUND: Although cardiac resynchronization therapy (CRT) is beneficial in most heart failure patients, up to 40% do not respond to CRT. It has been suggested that multipoint left ventricle pacing (MPP) would increase the response rate. AIM: To assess the CRT response rate at 6 months in patients implanted with a CRT device with the MPP feature activated early after the implant. METHODS This was a multicentre, prospective, open-label and non-randomized study. The primary endpoint was response to biventricular pacing defined as >15% relative reduction in left ventricular end-systolic volume (LVESV) comparing echocardiography measurements performed at baseline and 6 months by a core laboratory. Among secondary endpoints the combined endpoint of mortality or all-cause hospitalizations was evaluated. Primary study endpoint and clinical outcomes were compared to a Quarto II control cohort. RESULTS: 105 patients were included. The response rate was 64.6% (97.5% lower confidence bound 53%). Mean relative reduction in LVESV was 25.3% and mean absolute increase in LVEF was 9.4%. The subjects with device programmed using anatomical approach had showed a trend toward higher responder rate than those using the electrical approach (72% vs. 61.1%, p= 0.32). Compared with Quarto II, the combined endpoint of mortality and or all-cause hospitalizations was lower in Quarto III (12.4% vs 25.4%, p=0.004). CONCLUSIONS: Early activation of MPP was not associated to an advantage increasing echocardiography responders to CRT at 6 months of follow up. Nevertheless, MPP was associated with better clinical outcomes in comparison to a historical control cohort. Patients programmed using widest pacing cathodes had a numerically higher responder rate.