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Total Intravenous Anaesthesia with Propofol-a comparison of Target-controlled infusion (TCI) with manual controlled infusion (MCI). A randomized study
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  • Abiodun Jasper,
  • Badare Paul Efe,
  • Edomwonyi Philomina Nosa,
  • Amanor-Boadu Simbo
Abiodun Jasper
Delta State University

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Badare Paul Efe
Delta State University
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Edomwonyi Philomina Nosa
University of Benin Teaching Hospital
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Amanor-Boadu Simbo
University College Hospital Ibadan
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Background Total Intravenous Anaesthesia (TIVA) with propofol infusion is done by manual co’ntrolled infusion (MCI) or by target-controlled infusion (TCI) devices. This is a comparative study of MCI/TCI administration. Method In this randomized controlled trial, Anaesthesia was induced with propofol 1%, using a target blood concentration of 5 Meg/ml in the TCI group or at a dose of 1.5 mg/kg at an infusion rate of 1200 ml/h in the MCI group. Subsequently, a step-down maintenance regimen (10, 8 and 6 mg/kg/h at 10-min interval) was commenced for the MCI group. Primary outcome was the time to induction of anaesthesia in both groups. Data was analysed using Statistical Package for Social Sciences (SPSS) version 20.0. Results 52 patients were recruited into the study. The duration of induction of anaesthesia in the TCI group compared to the MCI group was (94.62 ± 11.34 sec vs. 79.50 ±16.23 sec, p = 0.001). The induction dose of propofol TCI against MCI was (118.00 ± 22.33 mg vs.133.04 ± 20.58 mg, p = 0.015). Both groups were comparable in terms of total dose of propofol (I 152.92 ± 234.47 mg vs. 1014.97 ± 264.18 mg, p = 0.052), recovery time (8.45 ± 2.13 min vs. 7.86 ± 2.05 min, p = 0.314), haemodynamic parameters and incidence of adverse events. Conclusion Manual controlled infusion was comparable to target controlled infusion for the induction and maintenance of general anaesthesia using propofol; providing similar quality and ease of anaesthesia as a viable option in resource challenged settings.