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Topical 5-Aminolevulinic Acid-Mediated Photodynamic Therapy versus Loop Electrosurgical Excision Procedure in the Treatment of Cervical Intraepithelial Neoplasia: A retrospective study, 2012–2019
  • +7
  • Yidi Liu,
  • Yi Li,
  • Jieyang Xu,
  • Huan Wu,
  • Ying Wang,
  • Jing Zeng,
  • Hui Li,
  • Hongjie Chi,
  • Haixia Qiu,
  • Ying Gu
Yidi Liu
First medical center of Chinese PLA General Hospital

Corresponding Author:[email protected]

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Yi Li
First medical center of Chinese PLA general hospital
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Jieyang Xu
First medical center of Chinese PLA general hospital
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Huan Wu
Chinese PLA General Hospital
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Ying Wang
First medical center of Chinese PLA general hospital
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Jing Zeng
First medical center of Chinese PLA general hospital
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Hui Li
First medical center of Chinese PLA general hospital
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Hongjie Chi
First medical center of Chinese PLA general hospital
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Haixia Qiu
First medical center of Chinese PLA general hospital
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Ying Gu
First Medical Center of Chinese PLA General Hospital
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Abstract

Abstract Objective: To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN). Design:Retrospective study. Setting:Department of Laser Medicine, the First Medical Centre, Chinese PLA General Hospital. Population or Sample:Female patients with a histologically confirmed CIN or HPV infection were treated by 5-ALA PDT or LEEP. Methods: Patients underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec. 2019 in Chinese PLA general hospital. Propensity score matching (PSM) was adapted to pair the baseline. Main Outcome Measures: Complete remission (CR), partial remission (PR) and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP. Results 30 pairs were matched as the matching tolerance was set as 0.03. There was no significant difference about the CR and PR between 5-ALA PDT and LEEP group (73.33% vs 84.00%, P=0.340; 3.33% vs 4.00%, P=1.000). Among CIN1, 2, 3 group, there was also no statistic difference between 5-ALA PDT and LEEP. Moreover, in terms of HPV remission rate, 5-ALA PDT showed the same efficacy as LEEP (59.26% vs 53.85%, P=0.691). Conclusions In treating different types of CIN patients, Topical 5-ALA PDT is a successful, non-invasive, repeatable treatment with comparable results to LEEP.