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Whole genome sequencing and molecular epidemiology of the 2021 African swine fever virus outbreak in the Dominican Republic
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  • Steven M. Lakin,
  • Vivian O'Donnell,
  • Lizhe Xu,
  • Roger W. Barrette,
  • Jamie Barnabei,
  • Rafael Nunez,
  • Robin Holland,
  • Bonto Faburay,
  • Suelee Robbe-Austerman
Steven M. Lakin
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Vivian O'Donnell
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Lizhe Xu
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Roger W. Barrette
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Jamie Barnabei
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Rafael Nunez
Dirección General de Ganadería Santo Domingo Dominican Republic
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Robin Holland
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Bonto Faburay
Foreign Animal Disease Diagnostic Laboratory National Veterinary Services Laboratories Veterinary Services Animal and Plant Health Inspection Service US Department of Agriculture Plum Island Animal Disease Center Plum Island New York USA
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Suelee Robbe-Austerman
USDA National Veterinary Services Laboratories
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Abstract

African swine fever (ASF) is a high-consequence transboundary disease of domestic and wild swine often characterized by high case mortality rates. On July 29, 2021, the Dominican Republic announced the African swine fever virus (ASFV) had been detected in samples collected in early- to mid-July 2021. Retrospective testing of samples collected as part of a collaborative surveillance project between the United States and the Dominican Republic identified ASFV in samples collected as early as May 13, 2021. These detections represent a new outbreak of ASF in the Dominican Republic, which had been declared free of the disease since 1981. Overall, 73 whole genomes of ASFV were sequenced from clinical samples received during the outbreak across 18 provinces. The genomic sequence data have been deposited in public databases to support and expand global data sharing on this impactful disease. While the sequences show a high degree of nucleotide identity to publicly available ASFV genomes from Europe and Asia, they are genetically distant from genomes in the public repositories by at least 8 previously undescribed single nucleotide polymorphisms.
19 Jul 2022Submitted to Transboundary and Emerging Diseases
20 Jul 2022Assigned to Editor
20 Jul 2022Submission Checks Completed
24 Jul 2022Reviewer(s) Assigned
22 Sep 2022Review(s) Completed, Editorial Evaluation Pending
22 Sep 2022Editorial Decision: Revise Major