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Correlation between urinary and serum NT-proBNP in acute bronchiolitis. A pilot study
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  • Moises Rodriguez-Gonzalez,
  • Ana Castellano-Martinez,
  • Ana Estalella-Mendoza,
  • Patricia Rodríguez-Campoy,
  • Lorena Estepa-Pedregosa,
  • María Mercedes Calero-Ruiz,
  • Ana Sáez-Benito Godino,
  • J. Carlos Flores-González
Moises Rodriguez-Gonzalez
Hospital Universitario Puerta del Mar

Corresponding Author:[email protected]

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Ana Castellano-Martinez
Hospital Universitario Puerta del Mar
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Ana Estalella-Mendoza
Hospital Universitario Puerta del Mar
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Patricia Rodríguez-Campoy
Hospital Universitario Puerta del Mar
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Lorena Estepa-Pedregosa
Hospital Universitario Puerta del Mar
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María Mercedes Calero-Ruiz
Hospital Universitario Puerta del Mar
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Ana Sáez-Benito Godino
Hospital Universitario Puerta del Mar
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J. Carlos Flores-González
Hospital Universitario Puerta del Mar
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Abstract

Background and aims: We aimed to analyze the correlation of urinary with serum NT-proBNP concentrations in acute bronchiolitis and its association with the severity of the disease.  Material and Methods: A pilot observational study conducted between 1st October and 31st March 2022, including acute bronchiolitis cases who attended our institution. Serum and urinary NT-proBNP concentrations were determined using the Alere NT-proBNP assay in time-matched urine and blood samples. We explored the linear relationship between both concentrations and compared clinical outcomes indicative of severe acute bronchiolitis between groups of raised and normal urinary NT-proBNP.  Results: 17 infants (median age 68 (36-91) days) with 36 time-matched samples were included. The urinary and serum concentrations of NT-proBNP were significantly correlated with (r=0.867 & R-squared coefficient=0.751; p<0.001). The log-10-transformed urinary NT-proBNP concentrations were higher at the time of hospital admission in those infants that required PICU admission with ventilatory support compared with those without this outcome (1.85 (1.16-2.44) pg/mg vs 0.63 (0.45-0.84) pg/mg); p<0.001); and resulted positively and strongly correlated with the duration of the ventilatory support (rho=0.76; p<0.001) and the LOS hospitalization (rho=0.84; p<0.001) Conclusion: The measurement of urinary NT-proBNP concentrations could be a reliable surrogate for serum NT-proBNP levels highlighting the potential value of the urinary NT-proBNP as a non-invasive tool to assess severity in acute bronchiolitis.
05 Jul 2022Submitted to Pediatric Pulmonology
05 Jul 2022Submission Checks Completed
05 Jul 2022Assigned to Editor
11 Jul 2022Reviewer(s) Assigned
01 Aug 2022Review(s) Completed, Editorial Evaluation Pending
01 Aug 2022Editorial Decision: Revise Minor
26 Sep 20221st Revision Received
26 Sep 2022Submission Checks Completed
26 Sep 2022Assigned to Editor
26 Sep 2022Reviewer(s) Assigned
16 Oct 2022Review(s) Completed, Editorial Evaluation Pending
23 Oct 2022Editorial Decision: Accept
13 Nov 2022Published in Pediatric Pulmonology. 10.1002/ppul.26215