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Interplay between hydrogen and chalcogen bond in cysteine
  • Oliviero Carugo
Oliviero Carugo
Universita degli Studi di Pavia Dipartimento di Chimica

Corresponding Author:oliviero.carugo@univie.ac.at

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Protein structures are stabilized by several types of chemical interactions between amino acids, which can compete with each other. This is the case of chalcogen and hydrogen bonds formed by the thiol group of cysteine, which can form three hydrogen bonds with one hydrogen acceptor and two hydrogen donors and a chalcogen bond with a nucleophile along the extension of the C-S bond. A survey of the Protein Data Bank shows that hydrogen bonds are about 40-50 more common than chalcogen bonds, suggesting that they are stronger and, consequently, prevail, though not always. It is also observed that frequently a thiol group that forms a chalcogen bond is also involved, as a hydrogen donor, in a hydrogen bond.
29 Jun 2022Submitted to PROTEINS: Structure, Function, and Bioinformatics
29 Jun 2022Submission Checks Completed
29 Jun 2022Assigned to Editor
25 Aug 2022Reviewer(s) Assigned
20 Sep 2022Review(s) Completed, Editorial Evaluation Pending
21 Sep 2022Editorial Decision: Revise Major
06 Oct 20221st Revision Received
06 Oct 2022Submission Checks Completed
06 Oct 2022Assigned to Editor
06 Oct 2022Reviewer(s) Assigned
07 Oct 2022Review(s) Completed, Editorial Evaluation Pending
13 Oct 2022Editorial Decision: Accept
26 Oct 2022Published in Proteins: Structure, Function, and Bioinformatics. 10.1002/prot.26437