Objective: To estimate the incidence of influenza-associated hospitalizations and deaths in Brazil from 2010 to 2016. Method: Records of hospital discharges and deaths (mortality system) were used by ICD codes J09-J18, data from laboratory influenza surveillance, and census population projections adjusted by the percentage of those using public health services. Meta-analysis was performed to determine the incidences of hospitalizations and deaths by age group in the five geographic regions of Brazil. Results: The estimates were 645,661 hospitalizations and 160,089 deaths from influenza from 2010 to 2016. The highest incidences of hospitalization occurred in older adults with ≥65 years (258.6/100.000) and children <5 years old (180.1/100,000), while deaths stood out among individuals aged ≥65 (142.9/100,000) and aged 50 to 64 years (22.1/100,000). Regional differences were found, with higher incidences predominantly in the Midwest, Southeast, and South regions. Conclusion: The burden of influenza in Brazil is of concern, with a high number of hospitalizations and deaths from the disease. Regional and age group differences provide evidence to support vaccination policy and the improvement of the influenza surveillance system. Key Words: Human Influenza, Incidence, Mortality, Hospitalization, Meta-analysis