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Can Lapascopic Nerve-Sparing Ultra-Radical Hysterectomy be used for locally advanced cervical cancer? ---Single-center retrospective study
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  • Wei-wei Wei,
  • Hong Zheng,
  • Xia Chen,
  • Yi-fei Min,
  • Bin Tang,
  • Huiting Sun,
  • jiming chen,
  • Ru-xia Shi
Wei-wei Wei

Corresponding Author:[email protected]

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Hong Zheng
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Yi-fei Min
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Huiting Sun
The Affiliated Changzhou No 2 People's Hospital of Nanjing Medical University
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jiming chen
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Ru-xia Shi
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Abstract

Objective: To investigate the outcome of Laparoscopic Nerve-Sparing Ultra-Radical Hysterectomy (LNSURH), open radical hysterectomy (ORH), and concurrent platinum-based chemoradiation therapy (CCRT) on patients with locally advanced cervical carcinoma (LACC). Design:Retrospective clinical study. Population:LACC patients (74) who received ORH (29), LNSRH (20), or CCRT (25) between January 2011 and December 2019 at the Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University. Methods: The age, tumor size, early and late postoperative morbidities, disease-free survival (DFS), and overall survival (OS) were recorded. A series of questions regarding urinary, bowel, and sexual functions were asked to the patients after their operation. Results: The Kaplan Meier curves revealed that the OS and DFS times in the CCRT group were comparable to the ORH or LNSURH groups (P = 0.106 for DFS and 0.190 for OS). The rates of early complications in the CCRT, ORH, and LNSURH groups, were also not statistically significant differences among the three groups (P = 0.46). Compared with CCRT groups, the rate of late complications in the ORH and LNSURH groups was significantly lower. The urinary and bowel functions were restored to the preoperative state although the resultant sexual function was not satisfactory. Main outcome measures:Postoperative prognosis and life quality of these patients. Conclusion: The CCRT, ORH, and LNSURH can be provided as options for LACC patients as they showed no statistically significant difference in the OS and DFS. LNSURH exhibited a lower rate of late complications and a high score of sexual function.