loading page

An In-vitro Study on Post-surgical Breast Wound Healing Activity by Zinc Oxide Dots and its Optimization using Box Behnken Design
  • Mary Nancy Flora R
Mary Nancy Flora R

Corresponding Author:[email protected]

Author Profile


In spite of the discovery of various medicines to heal post-surgical malignant wounds caused by the recurrence of breast cancer cells after chemotherapy, still it’s a serious problem to heal malignant wounds completely for surgeons and this has to be cured in order to avoid further risk of wound issues. This study is one such attempt taken to give a solution to heal surgical breast wounds for the future analysts. For this purpose, we have synthesized a novel bio-compatible fluorescent quantum dot using curcumin-loaded Zinc oxide bionanocomposite (Cur-ZnOBC). The ZnOBC is composed of neem essential oil-Aloe-vera gel complex which acted as a nanoconjugate for the formation of Cur-ZnOBC.Then it is converted into curcumin-based quantum dots (Cur-ZnOQDs) using microwave-assisted method in order to improve the drug delivery purpose. The resulting Cur-ZnOQDs was treated in the malignant wounds of breast cancer cells post-surgery for wound healing activity. The synthesized Cur-ZnOQDs was characterized to confirm its size and morphology. Thus, prepared Cur-ZnOQDs showed low cytotoxicity (IC50 0.17 µg/mL) to human breast cancer cells. Cell death was noticed at a very low concentration of 0. 6mg/mL itself. It was also found that wound closure area was increased from 22.3% at 24 h to 44.2% at 48 h which was 20 times greater cell migration when compared to control (untreated cells) and at a very low concentration of Cur-ZnOQDs (0.1mg/mL). Hence, Cur-ZnOQDs act as bio-enhancers assisting in the improvement of outcomes associated with breast cancer and, ultimately, improving the survival rate.