Brief analysis on the role of RNA-binding proteins in prognosis of
endometrial cancer based on TCGA
Abstract
Background Recently, it has been demonstrated that the disturbance of
RNA-binding proteins is closely related to the occurrence, progression
and prognosis of diseases and cancers. Meanwhile, the role of RBPs in
endometrial cancer remains to be explored. Objective To find out the
prognostic role of RBPs in endometrial cancer. Methods Unit COX
regression analysis, LASSO, multivariate COX regression analysis,
Kaplan–Meier survival analysis. Results We obtained endometrial cancer
RNA sequencing data and clinical data from TCGA, screened 284
differentially expressed genes that were differentially expressed
between cancer tissues and normal tissues, performed functional
enrichment analysis on them, and then screened from the differentially
expressed genes identified prognostic-related genes (CD3EAP, EPHB6,
CIRBP, LTK, ADARB2, RBPMS), developed a prognostic model to examine
differences in OS among patients in high- and low-risk cohorts, and
constructed a nomogram to predict patient survival rate. Conclusions We
use public databases to study that RBPs have certain value in the
occurrence and development of endometrial cancer, and can be used as a
prognostic marker for endometrial cancer.