Abstract: Background: Plasma kinins are known for decades but the
understanding of them is not up-to the mark and the complexity is the
reason. There are many drugs and trials undertaken with these as drug
targets but only very few have been successfully marketed and used. Rest
all others have resulted in failure during various phases of the trial.
Purpose: The purpose of this review is to explain and explore the
complexity of plasma kinins and to explore the relations between Kinins
and to analyse the failures in drug development with these receptors as
targets. Implication: This extensive review might help in understanding
the complexity and ensure the reduction of drug development failures in
these molecules as drug targets Conclusion: kinins have important role
in homeostatic functions of the body physiologically. The
pathophysiological roles in inflammation are also known. The complexity
of these systems is well established.