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Maternal and umbilical cord 25(OH)D levels at delivery and identification of factors affecting the correlation: a prospective observational study from a northern Emirate.
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  • Magnus Jutell,
  • Maria Bagge,
  • Shakura Bhat,
  • Per-Erik Isberg,
  • Nana Wiberg
Magnus Jutell
Lund University Faculty of Medicine

Corresponding Author:[email protected]

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Maria Bagge
Sheikh Khalifa Medical City Ajman
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Shakura Bhat
Sheikh Khalifa Medical City Ajman
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Per-Erik Isberg
Lund University
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Nana Wiberg
Lund University
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Abstract

25-hydroxyvitamin-D (25(OH)D) level in the fetus entirely depends on the transport over placenta which is assumed to be obstructed with maternal levels <25nmol/L. Design Observational study. Setting Prospectively enrolling from September to December 2021 in a tertiary governmental hospital in a northern Emirate. Population Admission for spontaneous and elective labor. Methods 25(OH)D was analyzed in maternal serum at admission, respectively, in cord blood after delivery. Main outcome measures Factors affecting maternal and fetal 25(OH)D levels and the correlation between the two at delivery. Results 303 women were enrolled and 237 had complete maternal/umbilical cord blood samples. 138 (47.7%) of women were diagnosed with deficiency (25(OH)D<50nmol/L), whereas only 34 fetuses (13.8%) were deficient (25(OH)D<30nmol/L). The mean difference between maternal and cord blood 25(OH)D was negative in 91% of cases (-16.27nmol/L, SD=13.36). The correlation between maternal/umbilical cord levels was excellent (r = 0,906, p<0,000). After dividing into subgroups of maternal 25(OH)D levels, BMI, diabetes yes/no and delivery-mode the correlation was consistent, although the correlation coefficients in the subgroups of maternal 25(OH)D levels were lowered for all groups. Of factors studied, only the supplementation dose affected the maternal 25(OH)D level. 25(OH)D <50nmol/L was not associated to an increased risk for diabetes, preterm labor, preterm-rupture-of-membranes or low Apgar-score. Conclusion We found a higher 25(OH)D level in cord blood with consistent correlation to maternal levels. Of the studied factors only supplementation dose had significant impact on the maternal level. 25(OH)D <50nmol/l were not associated to increased risk for preterm-labor, preterm-rupture-of-membranes, diabetes or low AS.