Pump-assisted coronary artery bypass grafting with low ejection
fraction: challenges and disparities in predicting and comparing
outcomes to the Society of Thoracic Surgeons risk calculator and
database.
Abstract
Background: Coronary artery bypass grafting (CABG) may
be performed with or without cardiopulmonary bypass (CPB). The Society
of Thoracic Surgeons (STS) provides a preoperative risk assessment tool
for CABG and reports postoperative outcomes from a database that is
updated quarterly. This manuscript aimed to analyze the preoperative
risk and postoperative outcomes in a subset of CABG patients with
ejection fraction < 40% utilizing a pump-assisted
beating-heart technique. These study results were compared to the STS
risk calculator and database. Methods: A single-center
observational study of 108 patients undergoing pump-assisted direct
coronary artery bypass (PAD-CAB) surgery with an ejection fraction
< 40% were examined. All patients were evaluated
preoperatively with the STS risk assessment calculator. Postoperative
outcomes were compared with the expected outcomes using the Wilcoxon
signed-rank test and the area under the receiver operating
characteristic curve (AUC). Results: The STS-predicted
rates for mortality (3.3% vs 2.7%, P = 0.11) and composite
morbidity or mortality (21.4% vs 7.4%, P < .001) were
higher than the observed. STS showed poor discriminatory power for
mortality (AUC = 0.48), reoperation (AUC = 0.48), morbidity (AUC = 0.51)
and prolonged length of stay (AUC = 0.62). Discussion:
PAD-CAB results compare favorably to the STS database predicted outcomes
for CABG. However, comparison of the study group to STS is problematic
because specific STS risk calculator definitions are subjective, and
database outcomes do not consider the technique of PAD-CAB. Further
refinements in these areas are necessary.