On the fractional optimal control problems of Hepatitis B with the
Caputo operator
- Jingwen Zhang,
- Yize Zhou,
- Zhigang Wang,
- Haohua Wang
Abstract
The long memory effects of a system can be regarded as fractional. This
paper deals with a newly constructed system of equation for Hepatitis B
disease of fractional control problems in sense of Caputo fractional
order derivative. The model considers four different health classes of
populations, susceptible, acute infections, chronic infections and
recovered, as well as a control by applying a strategy of isolation,
treatment and vaccination. Initially, the equilibrium points and
stability of the system are studied and sensitivity analysis
complemented by simulation is performed to determine how changes in
parameters affects the dynamical behavior of the system. For singular
kernel of fractional derivative, the necessary conditions for optimality
of Hepatitis B system are derived. An effective numerical simulation
depended on trapezoidal approximation is to verify the control effect in
terms of the transient response compared to the different fractional-
and integer-order derivatives, and additional graphical solutions are
presented for ease of understanding. This study may provide a strong
theoretical basis for uncovering the importance of the long memory
effects in the control of hepatitis B.