Antibiotic resistance is one of the greatest public health threats we face. Approximately 2 million infections and 23,000 deaths are a result of antibiotic-resistant bacteria in the United States every year. It occurs when bacteria acquire immunity to antibiotic treatments. In response, pharmaceutical companies usually develop new or improved antibiotics. However, as consumers overuse and misuse these treatments, multidrug-resistant bacteria with no effective treatment(s) emerge. Unfortunately, the proliferation of such microbes threatens to return society to pre-antibiotic era health conditions. Fortunately, phage therapy offers a potential solution. Phage therapy uses bacteriophages, viruses that exclusively infect bacteria, to target and kill antibiotic-resistant microbes at infection sites. This paper explores phage therapy and the challenges faced by researchers in developing it. It concludes with a discussion on the importance of phage therapy in the future on a global level.