Introduction: Cancers in children under the age of 17 have specific epidemiological and management aspects. The objective of this study was to determine the epidemiological and histological profile of childhood cancers in Lubumbashi. Method: A cross-sectional descriptive study conducted at the University Clinics of Lubumbashi over a lap of two-year. The data collection was done using a form with a number of parameters. Results: We noted a prevalence of (3.27%) childhood cancer in Lubumbashi and the percentage had increased in 2018 (53.5%) comparing to the previous years. The average time between the onset of the disease and the first consultation was 33.5-7.1 weeks and only (71%) cases had consulted a general practitioner at first sign of the disease. From the histological point of view retinoblastoma led the way with 29.2%, followed by Nephroblastoma (23.3%), lymphomas of all forms (13.2%). Other types of cancers were repeated, representing 28.3%. Conclusion: This pathology is a reality that is experienced in large numbers in our environment diagnosis and early treatment remain essential to the reduction of the mortality rate