The COVID-19 pandemic is still continuing. Current major variants of SARS-CoV-2 (Delta and Omicron) have lead to new uncertainties. Since the infection of SARS-CoV-2 and its major variants has been a high risk factor of cardiovascular health due to major adverse cardiovascular events (MACCE) and outcomes. Thus, the more coverage of vaccination, enough health workers, and related medical resources as well as the “ISISI” barriers from locals or regions to the globe play a critical role in combating COVID-19 and protection of human cardiovascular health.