Ewing sarcoma is an aggressive malignancy of bone and soft tissue that
accounts for approximately 2% of cases of childhood cancer. It has been
rarely reported as a secondary neoplasm. Data from the Childhood Cancer
Survivor Study has evaluated secondary sarcomas in 5-year survivors of
childhood cancer. We report two pediatric patients in northeast
Pennsylvania, who developed secondary Ewing Sarcoma of the 9th rib
within 5 years of primary childhood leukemia diagnoses.