Evaluation of Left ventricle ejection fraction, Serum Ferritin and C -
reactive protein as Early Prognostic Markers in Children with Sepsis.
Abstract
Sepsis, still cause morbidity and mortality in children admitted to the
pediatric intensive care unit (PICU). Several diagnostic and biological
markers have y been studied to monitor unfavorable evolution of sepsis
in critically ill patients but didn’t established. Objective: This study
aimed to evaluate the Left ventricle ejection fraction, serum Ferritin
and C - reactive protein and find out their value as early prognostic
markers for outcomes in pediatric sepsis in PICU. Patients and Methods:
40 patients admitted to a PICU diagnosed with sepsis. Echocardiography
study: to figure out the ejection fraction (EF) of the left ventricle,
serum levels of C-reactive protein and ferritin on D1 and D3 after
admission. Patients followed to detect their outcomes and mortality.
Results: We found with cardiac dysfunction by echocardiogram and
elevated ferritin levels on D1 had longer hospital stay in, prolonged
duration of mechanical ventilation use, higher maximum inotropic score,
and fewer ventilator-free hours. Both low Left ventricle ejection
fraction and high serum Ferritin are associated with unfavorable
outcomes. Conclusion: Cardiac dysfunction by echocardiogram (EF
< 55%) and serum ferritin values (≥300 ng/mL) on D1 of
admission in pediatric patients with sepsis admitted to the PICU, were
significantly associated with unfavorable outcomes.