Translating cognitive effect of neurogenesis augmentation by
antipsychotic drugs in schizophrenia: growth factors in the loop
Abstract
Neurogenesis is a dynamic trophic process, which produces enormous
number of new neurons per day in the adult brain. New neurons
participate in synapse circuit formation, and gaining discrete brain
functions including memory, and cognition. Various learning activities
and therapeutic agents, which increase neurogenesis also improve memory
and cognition in rodents suggesting that neurogenesis could be a
potential avenue for treating cognitive disabilities. In schizophrenia,
while reducing psychosis is a priority, improving cognition is
considered crucial for integrating patients into the academic and
working environment. However, the most commonly prescribed antipsychotic
drugs (APD), despite increasing neurogenesis, either do not improve or
show marginal effect on cognition in schizophrenia. Molecular mechanisms
that render APD ineffective in improving cognition are unclear; however,
neurotrophic factors, which regulate all aspects of neurogenesis, could
provide valuable clues. Therefore, in this review APD’s influence on
cognition, neurogenesis, and on growth factor deficit in schizophrenia
is discussed.