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Glycated Hemoglobin and Angiographic Severity in Chinese Patients with Coronary Artery Disease: a Retrospective Cohort Study
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  • Xueying Chen,
  • Yugang Yan ,
  • Ronghua Gao,
  • Shaohui Zhang,
  • Zhencai Gao ,
  • Anyong Chen ,
  • Jianjun Wang ,
  • Shufang Zhang ,
  • Wen Dai ,
  • Fen Li ,
  • Tengteng Ren ,
  • Guoliang Yang ,
  • Lixin Liu
Xueying Chen
Affiliated Hospital of Jining Medical University

Corresponding Author:[email protected]

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Yugang Yan
Jining Medical University
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Ronghua Gao
Affiliated Hospital of Jining Medical University
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Shaohui Zhang
Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, 
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Zhencai Gao
Affiliated Hospital of Jining Medical University
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Anyong Chen
Affiliated Hospital of Jining Medical University
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Jianjun Wang
Affiliated Hospital of Jining Medical University
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Shufang Zhang
Affiliated Hospital of Jining Medical University
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Wen Dai
Affiliated Hospital of Jining Medical University
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Fen Li
Jining Medical University
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Tengteng Ren
Affiliated Hospital of Jining Medical University
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Guoliang Yang
Affiliated Hospital of Jining Medical University
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Lixin Liu
Affiliated Hospital of Jining Medical University
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Abstract

Background: Many studies have shown that Glycated hemoglobin (HbA1c) is associated with Coronary Artery Disease (CAD). HbA1c was independently related to angiographic severity in Chinese patients with CAD after adjusting for other covariates. Some traditional cardiovascular drugs may have an impact on this relationship. Methods: This retrospective study enrolled a total of 572 CAD patients who underwent their coronary angiography and had their HbA1c levels measured at the Chinese Hospital. The complexity of the coronary artery lesions was evaluated using the Syntax score, and the subjects were divided into 4 inter quartiles according to HbA1c levels. Covariates included history of traditional cardiovascular drugs. Results: The average age of selected participants was 61.00 ± 9.15 years old,and about 54.72% of them was male. Result of fully-adjusted linear regression showed HbA1c was positively associated with Syntax score after adjusting confounders (β=1.09, 95%CI: 0.27, 1.91, P=0.0096). By interaction and stratified analyses, the interactions were observed based on our specification including: with the medication history of Statins and Angiotensin Receptor Blockers (ARBs) (P values for interaction <0.05). Conclusions: In this study, we found a positive correlation between the HbA1c levels and the SYNTAX score among CAD individuals, and oral Statins and ARBs medication could affect the correlation. Thus, HbA1c measurement could be used for the evaluation of the severity and complexity of coronary lesions among CAD patients.