Complete resolution of alopecia totalis following chemotherapy treatment
for B-cell acute lymphoblastic leukemia
Alopecia totalis (AT) is a chronic disease that results in non-scarring
hair loss of the entire scalp. This results from an autoimmune reaction
involving the hair follicles due to genetic and environmental factors.
The clinical course of AT is highly unpredictable. There are limited
effective durable treatment options. Resolution of alopecia has been
reported post-autologous and allogenic hematopoietic stem cell
transplantation (HSCT). However, no cases of AT remission following
chemotherapy alone have been described. Here, we present a case of
complete remission of AT following chemotherapy for B-cell acute
lymphoblastic leukemia (B-ALL) in a pediatric patient.