Introduction There are few reports regarding risk of COVID-19-associated
complications in bone marrow recipients. We report a patient who had
graft-versus-host disease triggered by COVID-19. Results The patient was
a 17-year-old boy who underwent HSCT from matched sibling donor for CML.
He had complete donor chimerism at day +30. Cyclosporine was tapered and
stopped at day +65. Until day +93, he had no complaints. The patient
started to suffer from cutaneus and gastro-intestinal grade III GVHD
after the diagnossis of CIVID-19. Discussion In the absence of any other
condition to explain this clinical picture and the good response to GVHD
treatment indicate that the triggering factor in the development of GVHD
may be COVID-19 in the era of TLR, which plays a common role in the
pathogenesis of both GVHD and COVID-19.