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Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multi-center hospitals in Guangdong, China
  • Lei Zheng
Lei Zheng
Southern Medical University Nanfang Hospital

Corresponding Author:[email protected]

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Abstract

Background: Acute respiratory infections (ARI) cause a considerable morbidity and mortality worldwide especially in children. Unfortunately, there was limited multi-center data about common viral respiratory infection in south China. Methods: A total of 4403 nasal swabs of children were collected from 10 cities of Guangdong, China in 2019. Seven respiratory viruses including influenza A virus (IFA), influenza B virus (IFB), respiratory syncytial virus (RSV), adenoviruses (ADV), parainfluenza virus type 1-3 (PIV1-3) and were detected by direct immunofluorescence antibody assay. The personal information and clinical characteristics were recorded and analyzed. Results: The results showed that 1099 (24.96%) samples were detected of at least one virus. The detected rates of RSV, IFA, ADV, PIV3, PIV1 and PIV2 were 7.13% (314/4403), 5.31% (234/4403), 4.02% (177/4403), 3.04% (134/4403), 1.70% (75/4403) and 1.16% (51/4403), respectively. The detection rate of RSV in (0-6)-month-old was highest with 18.18% (106/583), while the detection rate of IFA in (12-18)-year-old was highest with 20.48% (17/83). The total detection rates in winter and spring were 35.67% (219/614), 34.56% (403/1166), higher than those in summer 17.41% (284/1631) and autumn 19.46% (193/992). Conclusions: RSV and IFA were the main respiratory viruses in children. With age, the detection rate of RSV decreased in children, but the trend of detection rates of IFA and IFB were the opposite. This study provided the viral etiology and epidemiology of pediatric patients with ARI in Guangdong, China, which was important for the improvement and optimization of diagnostic tactics, control and prevention of the respiratory viral infections.