The current analytical examination supports nanofluids with peristaltic flow motion in a confined length of non-uniform horizontal tube with an endoscope using Buongiorno’s nanofluid model. The consideration based on three geometries of Gold –blood MHD nanoparticles (sphere, cylinders and blades) in addition to wall properties, thermal and velocity slip affects. This model is studied for biomedical applications in various fields. Equations and boundary conditions are modeled and formed in some dimensionless control equations for the realistic study of the model. Exact solutions with nanoparticle shape effects on temperature, velocity, heat transfer and stream function expression are obtained. Visual depiction for these solutions under the study of variation of various parameters are demonstrated. Few observations illustrate that platelet shape nanoparticles attain highest thermal conductivity. Maximum and increasing behavior of temperature experienced for sphere shape nanoparticles and for higher values of thermal slip parameter. Increasing conduct of velocity profile is also seen for large values of velocity slip parameter and sphere shape nanoparticles shows dominance as compared to brick and platelet shape particles. Trapping phenomenon is also discussed for the desirability of present study. Design of micro peristaltic pump for the transport of nanofluids and drug delivery system that offers various drug geometries are the main use of this model.