Vitex agnus-castus Linn referred as a small decides tree commonly known as the chaste tree. The fruits of this tree have been used as a therapeutic agent for over 2500 years in ancient Egypt, Greece, Iran, and Rome. The Vitex Agnus belongs to the family of Verbenaceae which encompasses 250 species from all over the world and Vitex is the largest genus of this family. Vitex has many therapeutic and medicinal benefits the German health authorities have approved the utilization of V.agnus castus for treating irregularities of menstruation among females and also associated disorders, mastalgia, and menopausal disorders. Evidence based studies have proved multiple therapeutic and pharmaceutical benefits of this medicinal plant which includes antioxydant, anti-cancer, immunomodulatory antimicrobial, anti-inflammatory, anti-fungal, insect repellent, fracture healing, osteopenic, epileptic, anti-diabetic and it also prevents from nonalcoholic fatty liver disorders. The literature also suggests that there is no drug interaction associated with Vitex. Moreover, the use of V. agnus-castus is contraindicated (or ought to be abstained from) during pregnancy because of hypothetical sentiments and cell examines that displayed progesteronic and estrogenic properties of the plant. This review gives the documentation to researchers to utilise the properties of V. agnus-castus as a powerful natural medication and its wellbeing and satisfactory measurement are examined. Progressed preclinical and clinical examinations for adequately evaluating the security and helpful viability of V. agnus-castus are suggested.