Objective To study clinical efficacy and quality of life of sacrospinous ligament fixation in the treatment of pelvic organ prolapse. Design Retrospective analysis of clinical cases Setting China Population or sample 124 cases of patients with pelvic organ prolapse of The second affiliated hospital of anhui medical university were retrospectively analyzed from January 2013 to December 2019. Methods Perioperative information, postoperative complications, postoperative subjective recovery and postoperative quality of life questionnaire were observed and compared. According to different postoperative follow-up time, patients were divided into the <12 months group, the 12-24 months group, the 24-60 months group and the ≥60 months group, and the subjective postoperative recovery of patients in different groups was counted respectively. Main outcome measures POP-Q stages were in normal position after 3 months of postoperation, and the values of genital hole, perineal body, and total vaginal length were significantly different from those before operation (P<0.001). The results of the pelvic floor dysfunction questionnaire for 19 patients after 12 months of postoperation showed that the total PFDI-20 score was significantly different from that before surgery (P<0.001), the preoperative and postoperative scores of UDI-6(urogenital distress inventory) and POPDI-6(pelvic organ prolapse distress inventory) were significantly different (P<0.001). Preoperative and postoperative hemoglobin difference was statistically significant (P <0.001), while preoperative and postoperative residual urine values were not statistically significant (P >0.05). Conclusion Sacrospinous ligament fixation (SSLF) has a significant effect on the treatment of moderate and severe pelvic organs prolapse, and can effectively restore its anatomical structure.